The genetic potential of sorghum and millets is under-exploited in Uganda. There is over-reliance on the traditional conventional breeding schemes which account for the limited development of market-demanded varieties. Climate change requires breeding programs to deliver varieties faster. Innovative breeding approaches and improved methods of measuring traits for faster genetic gains are must-have capabilities for dynamic and futuristic breeding programs. Recent Breeding Program assessments identified gaps such as limited utilization of innovative breeding approaches and mismatch between improved varieties and target niche markets’ needs. CGIAR – NARES breeding network is innovatively integrating demand-led breeding following market segment and target product profile approach, with breeding innovations such as marker applications and improved breeding schemes to accelerate delivery of impactful varieties to farmers and other end users.